Am J Cardiovasc Dis 1(3):293–311Īnuradha CV, Balakrishnan SD (1999) Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Ībebe W, Mozaffari MS (2011) Role of taurine in the vasculature: an overview of experimental and human studies. Ībebe W, Mozaffari MS (2003) Taurine depletion alters vascular reactivity in rats. Clarifying the mechanisms in which taurine affects the vascular system may facilitate the development of therapeutic and/or diet-based strategies to reduce the burden of vascular diseases.Ībebe W, Mozaffari MS (2000) Effect of chronic taurine treatment on reactivity of rat aorta. To date, the molecular mechanism(s) involved in the vascular effects of taurine are largely unknown and require further investigation. We have recently shown that taurine relaxes human internal mammary and radial arteries by opening large conductance Ca 2+-activated K + channels. Several studies showed that taurine relaxed various animal arteries through opening potassium channels. In isolated animal arteries, taurine exerts vasodilation through endothelium-dependent and independent mechanisms. Both central and peripheral actions of taurine may be involved in its hypotensive effects. taurine administration reduces blood pressure in hypertensive patients. It is well established that supplementation of taurine prevents development of hypertension in several animal models and p.o. This review summarizes the role of taurine in vascular tone and blood pressure modulation based on experimental and human studies. Taurine is widely distributed at high concentrations in mammalian tissues, and it plays an important role in a wide range of biological effects including modulation of cardiovascular functions.
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